Macromolecular Structure and Interactions

The interactions of macromolecules in UVA's Macromolecular Structure and Interactions lab.A detailed knowledge of the synthesis, structure, function and interactions of macromolecules is a necessity for the full understanding of cellular processes. Numerous researchers at the University of Virginia are involved in state-of-the-art research in these areas. Studies include: the mechanisms of polypeptide chain folding; the three-dimensional configuration of proteins; interactions of proteins with other proteins, nucleic acids and phospholipids; relationship between the plasma membrane and the cytoskeleton and extracellular matrix; and structure-function relations and domain structure of enzymes. Each of these studies includes current technology and instrumentation, including x-ray crystallography, multi-dimensional NMR spectrometry, differential scanning microcalorimetry, fluorescence depolarization, scanning and transmission microscopy and atomic-force microscopy, tandem mass spectrometry, Fourier transform infrared spectrometry, affinity labelin; laser-induced protein/nucleic acid cross-linking, immunofluorescence, hybridoma and recombinant DNA technology, and computer simulation.

Faculty in this area:

David Auble

Auble, David T.

Molecular Mechanisms of Transcriptional Regulation

John Bushweller

Bushweller, John H.

Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer

Steven Caliari

Caliari, Steven

Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment

Linda Columbus

Columbus, Linda

Biophysical Chemistry: Membrane protein structure, function, and dynamics

Edward Egelman

Egelman, Edward H.

Structure and Function of Macromolecular Complexes Using Electron Microscopy

Peter Kasson

Kasson, Peter M.

Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.

Wladek Minor

Minor, Wladek

Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility

Owen Pornillos

Pornillos, Owen

Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system

Stefanie Redemann

Redemann, Stefanie

Chromosome segregation and aneuploidy in meiosis and mitosis

P. Todd Stukenberg

Stukenberg, P. Todd

Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

Lukas Tamm

Tamm, Lukas K.

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

Michael Wiener

Wiener, Michael C.

Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development

Mark Yeager

Yeager, Mark

Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus

Jochen Zimmer

Zimmer, Jochen

Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.