Immunology, Virology and Molecular Pathogenesis

Cells of the immune system recognize the presence of foreign substances or of virally infected cells in UVA's Immunology, Virology and Molecular Pathogenesis lab.Remarkable progress has been made in recent years in understanding the properties of infectious agents such as bacterial pathogens, viruses, and protozoa, which allow these organisms to cause disease. Equally important has been the definition of the immune system and how it responds to the presence of infectious agents. Researchers at the University of Virginia are interested in the mechanisms by which cells of the immune system recognize the presence of foreign substances or of virally infected cells and how the immune cells act to eliminate these invaders.

Other researchers focus on the properties of infectious agents and study the structure and assembly of viruses, including RNA tumor viruses, the HIV agent associated with AIDS, and other RNA- and DNA-containing viruses that are of medical importance. Other groups study the surface properties of fungi and amoeba that allow them to cause disease. It is only by understanding both the character of the infectious agents and the nature of the body’s response to these that we will be able to conquer the particular disease.

Faculty
Herve Agaisse

Agaisse, Hervé

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Anna Cliffe

Cliffe, Anna

Herpes Simplex Virus Infection of Neurons

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Victor Engelhard

Engelhard, Victor H.

Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity

Loren Erickson

Erickson, Loren D.

Immune mechanisms of pathogenic antibody production in allergy and autoimmunity

Jennifer Guler

Guler, Jennifer

Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum

Young Hahn

Hahn, Young S.

Immune regulation for HCV infection and chronic liver inflammation

Marie-Louise

Hammarskjöld, Marie-Louise

Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

Kevin Janes

Janes, Kevin A.

Systems-biology approaches to cancer biology and virology.

Peter Kasson

Kasson, Peter M.

Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.

Dean Kedes

Kedes, Dean H.

Human Herpes virus associated with malignancy, including Kaposi's Sarcoma

Jason Papin

Papin, Jason A.

Systems biology, infectious disease, cancer, toxicology, metabolic engineering

Edward Perez-Reyes

Perez-Reyes, Edward

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Owen Pornillos

Pornillos, Owen

Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

David Rekosh

Rekosh, David M.

Human Immunodeficiency; Virus Gene Expression

Lukas Tamm

Tamm, Lukas K.

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

Martin Wu

Wu, Martin

Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts

Mark Yeager

Yeager, Mark

Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus

Jochen Zimmer

Zimmer, Jochen

Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.