Immunology, Virology and Molecular Pathogenesis
Remarkable progress has been made in recent years in understanding the properties of infectious agents such as bacterial pathogens, viruses, and protozoa, which allow these organisms to cause disease. Equally important has been the definition of the immune system and how it responds to the presence of infectious agents. Researchers at the University of Virginia are interested in the mechanisms by which cells of the immune system recognize the presence of foreign substances or of virally infected cells and how the immune cells act to eliminate these invaders.
Other researchers focus on the properties of infectious agents and study the structure and assembly of viruses, including RNA tumor viruses, the HIV agent associated with AIDS, and other RNA- and DNA-containing viruses that are of medical importance. Other groups study the surface properties of fungi and amoeba that allow them to cause disease. It is only by understanding both the character of the infectious agents and the nature of the body’s response to these that we will be able to conquer the particular disease.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Herpes Simplex Virus Infection of Neurons
Cellular and molecular mechanisms of Neisserial pathogenesis
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Systems-biology approaches to cancer biology and virology.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts
Cardiac Gap Junction Membrane Channels / IntegrinsWater Channels / Rotavirus / Reovirus / Retrovirus
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.