Signal Transduction

Illustration of how cells communicate with each other in UVA's signal transduction lab.Some of the most exciting findings of the past decade have deciphered processes involved in biological signal transduction. These are processes by which cells communicate among themselves. Much is known about how cells detect the presence of hormones, contact with other cells, or the presence of nutrientsor other environmental signals, and how the cells respond to these signals by changing metabolism or gene expression. These studies have identified the role and nature of viral oncogenes, which, when expressed in a cell infected with a tumor virus, disrupt normal controls over growth properties and result in a transformed or tumor cell. These viral oncogenes are derived from normal cellular regulatory proteins, and this fact allowed deduction of the normal signaling pathways. The role of protein kinases and alterations in calcium levels in signalling pathways have been established, in part by contributions from researchers at the University of Virginia.

Ongoing research centers on the identification and characterization of proteins that participate in various central signaling pathways and the mechanism by which these proteins interact with or influence their targets, such as the cytoskeleton or specific gene expression. Our researchers study both the normal signaling pathways in response to hormones and other environmental signals, and the perturbation of these pathways in cancer cells. Numerous studies focus on the circulatory system and the molecular aspects of the control of blood pressure and muscle function.

Faculty
Roger Abounader

Abounader, Roger

Basic and translational brain tumor research

Douglas Bayliss

Bayliss, Douglas A.

Mechanisms of neuromodulation in central neurons

Mark Beenhakker

Beenhakker, Mark P.

Circuit mechanisms of sleep and epilepsy

George Bloom

Bloom, George S.

Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders

Amy Bouton

Bouton, Amy H.

Signaling Pathways and Breast Cancer

Steven Caliari

Caliari, Steven

Engineering dynamic biomaterials to explore the interplay between cells and their microenvironment

James Casanova

Casanova, James E.

Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.

Mete Civelek

Civelek, Mete

Systems Genetics Approaches to Understand Cardiometabolic Traits

Jay Hirsh

Hirsh, Jay

Molecular genetics; development and function of neurotransmitter-synthesizing neurons in Drosophila

Brant Isakson

Isakson, Brant

Translating our discoveries in the microcirculation to tangible benefits in patients.

Kevin Janes

Janes, Kevin A.

Systems-biology approaches to cancer biology and virology.

David Kashatus

Kashatus, David F

The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

Mark Kester

Kester, Mark

Nanotechnologies for targeted drug delivery

Jonathan Kipnis

Kipnis, Jonathan

Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration

Norbert Leitinger

Leitinger, Norbert

Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

Kevin Lynch

Lynch, Kevin R.

Chemical biology of sphingosine 1-phosphate

Marty Mayo

Mayo, Marty W.

Transcriptional Regulation by NFKB

Golam Mohi

Mohi, Golam

Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.

Eyleen O'Rourke

O’Rourke, Eyleen Jorgelina

Obesity and Aging

Gary Owens

Owens, Gary K.

Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

Jason Papin

Papin, Jason A.

Systems biology, infectious disease, cancer, toxicology, metabolic engineering

Bryce Paschal

Paschal, Bryce M.

Nuclear Transport, Signaling, and Cancer

Shayn Peirce-Cottler

Peirce-Cottler, Shayn M.

Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

Edward Perez-Reyes

Perez-Reyes, Edward

Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.

Owen Pornillos

Pornillos, Owen

Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system

Benjamin Purow

Purow, Benjamin W.

Novel therapeutic approaches to brain cancers and to other neurologic diseases

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

Stefanie Redemann

Redemann, Stefanie

Chromosome segregation and aneuploidy in meiosis and mitosis

Jeffrey Saucerman

Saucerman, Jeffrey J.

Roles of complex signaling networks involved in the regulation of cardiovascular function and disease

Weibin Shi

Shi, Weibin

Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.

Jung-Bum Shin

Shin, Jung-Bum

Auditory Neurobiology

Sarah Siegrist

Siegrist, Sarah

Regulation of neural stem cell proliferation during development and adulthood

P. Todd Stukenberg

Stukenberg, P. Todd

Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

Christine Thisse

Thisse, Christine I.

Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine

B. Venton

Venton, B. Jill

Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

Bettina Winckler

Winckler, Bettina

Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.

David Wotton

Wotton, David

Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

J. Julius Zhu

Zhu, J. Julius

Neural Circuits in Healthy and Diseased Brains

Hui Zong

Zong, Hui

Early detection, cancer prevention, and tumor microenvironment