Planar signaling, polarity and morphogenesis.
Identify and target key genomic and epigenomic drivers in cancer
Molecular Mechanisms of Transcriptional Regulation
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Regulation of gene expression during lymphocyte development
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Signaling Pathways and Breast Cancer
Protein Phosphorylation in Cell Signaling
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins
Molecular Mechanisms for Membrane Transport and Cell Signaling
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.
Intracellular cholesterol and the regulation of insulin secretion and membrane trafficking.
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Regulation and Function Serotonergic Neurons During Development
Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Structure-function relationships in proteins
Ion channels and Ca2+-signaling in inflammation and immunity
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
Assembly and Function of Centromeric Chromatin
Molecular embryology--gene regulation in cells committed to specific developmental lineages
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Molecular Mechanics of Muscle Contraction and Cell Movement
Signal Processing by the Central Nervous System
Cell Adhesion and Morphogenesis; Cancer mechanisms; Cadherins and catenins; Hippo signaling pathway
Immune regulation for HCV infection and chronic liver inflammation
Regeneration and Systemic Responses to Tissue Damage
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Molecular mechanisms controlling insulin signaling and fat synthesis.
Molecular genetics; development and function of neurotransmitter-synthesizing neurons in Drosophila
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Cellular and molecular mechanisms of morphogenesis
Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Nanotechnologies for targeted drug delivery
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Regulation of Polarized Morphogenesis
The role of glia in the development, maintenance and regeneration of the nervous system
Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Neuroendocrine regulation of energy balance and stress, regulation of pancreatic islet hormone secretion and glucose homeostasis
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
Developmental regulation of planar cell polarity in the mammalian nervous system
Chemical biology of sphingosine 1-phosphate
Molecular Mechanisms of Myotonic Muscular Dystrophy
Pathogenicity of Francisella tularensis and vaccines
Transcriptional Regulation by NFKB
The Cause and Consequence of Somatic Mosaicism in Neurons
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Structure-Function of Active Transporters
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Nuclear Transport, Signaling, and Cancer
Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.
Regulation of Cytoplasmic Dynein for Membrane Bounded Organelle Trafficking in Axons
Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system
The Role of Melanopsin Retinal Ganglion Cells in the Photic Regulation of Mammalian Circadian Rhythms
Bioinformatics and computational genomics; Variation in genome structure; Somatic genome evolution; Cancer genome biology
Apoptotic cell clearance mechanisms in health and disease
Human Immunodeficiency; Virus Gene Expression
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
Mechanisms of actin assembly during cell migration and membrane traffic
Cellular and genetic determinants of atherosclerosis and restenosis.
Regulation of neural stem cell proliferation by extracellular factors, local and systemic. Intrinsic signaling programs regulating neural stem cell fate decisions: death versus survival. Functional and molecular similarities between Drosophila and mammal
Transcriptional Silencing and Aging in Yeast
Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle
Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Cell behavior and morphogenesis during early mouse development.
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Diabetic cardiovascular disease - early diagnosis and prevention; Women's heart disease.
Molecular control of embryonic development
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
Gene regulation during host-parasite interaction
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Targeting Cell Signaling for Cancer Therapy.
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
Structural biology (esp. crystallography) of integral membrane proteins; TonB-dependent active transport across the bacterial outer membrane; cancer-related membrane proteins; crystallization methods development
Endosomal function and dysfunction in neurons. Wiring the nervous system in development.
Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus
Mammalian kidney development
Neural Circuits in Healthy and Diseased Brains
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Early detection, cancer prevention, and tumor microenvironment