Faculty

Paul Adler

Adler, Paul N.

Planar signaling, polarity and morphogenesis.

Mazhar Adli

Adli, Mazhar

Identify and target key genomic and epigenomic drivers in cancer

David Auble

Auble, David T.

Molecular Mechanisms of Transcriptional Regulation

Paula Barrett

Barrett, Paula Q.

Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.

Douglas Bayliss

Bayliss, Douglas A.

Mechanisms of neuromodulation in central neurons

Mark Beenhakker

Beenhakker, Mark P.

Circuit mechanisms of sleep and epilepsy

Stefan Bekiranov

Bekiranov, Stefan

Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks

Timothy Bender

Bender, Timothy P.

Regulation of gene expression during lymphocyte development

George Bloom

Bloom, George S.

Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders

Amy Bouton

Bouton, Amy H.

Signaling Pathways and Breast Cancer

David Brautigan

Brautigan, David L.

Protein Phosphorylation in Cell Signaling

John Bushweller

Bushweller, John H.

Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer; Structural Studies of Membrane Proteins

David Cafiso

Cafiso, David S.

Molecular Mechanisms for Membrane Transport and Cell Signaling

James Casanova

Casanova, James E.

Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.<br> Cell Biology of bacterial pathogenesis. <br>The innate immune response to bacterial infection.

J. Castle

Castle, J. David

Intracellular cholesterol and the regulation of insulin secretion and membrane trafficking.

Linda Columbus

Columbus, Linda

Biophysical Chemistry: Membrane protein structure, function, and dynamics

Barry Condron

Condron, Barry G.

Regulation and Function Serotonergic Neurons During Development

Jeffrey Corwin

Corwin, Jeffrey T.

Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Christopher Deppmann

Deppmann, Christopher

Elucidating and Understanding the Mechanisms Underlying Nervous System Development

Zygmunt Derewenda

Derewenda, Zygmunt S.

Structure-function relationships in proteins

Bimal Desai

Desai, Bimal N.

Ion channels and Ca2+-signaling in inflammation and immunity

Douglas DeSimone

DeSimone, Douglas W.

Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis

Anindya Dutta

Dutta, Anindya

Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer

Noelle Dwyer

Dwyer, Noelle

Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance

Edward Egelman

Egelman, Edward H.

Structure and Function of Macromolecular Complexes Using Electron Microscopy

Daniel Engel

Engel, Daniel A.

Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

Victor Engelhard

Engelhard, Victor H.

Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance

Loren Erickson

Erickson, Loren D.

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

Daniel Foltz

Foltz, Daniel R.

Assembly and Function of Centromeric Chromatin

Robert Grainger

Grainger, Robert M.

Molecular embryology--gene regulation in cells committed to specific developmental lineages

Patrick Grant

Grant, Patrick A.

Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer

William Guilford

Guilford, William H.

Molecular Mechanics of Muscle Contraction and Cell Movement

Ali Guler

Guler, Ali D.

Signal Processing by the Central Nervous System

Barry Gumbiner

Gumbiner, Barry M.

Cell Adhesion and Morphogenesis; Cancer mechanisms; Cadherins and catenins; Hippo signaling pathway

Young Hahn

Hahn, Young S.

Immune regulation for HCV infection and chronic liver inflammation

Adrian Halme

Halme, Adrian J.

Regeneration and Systemic Responses to Tissue Damage

Marie-Louise

Hammarskjöld, Marie-Louise

Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

Thurl Harris

Harris, Thurl E

Molecular mechanisms controlling insulin signaling and fat synthesis.

Jay Hirsh

Hirsh, Jay

Molecular genetics; development and function of neurotransmitter-synthesizing neurons in Drosophila

Jeffrey Holmes

Holmes, Jeffrey W.

Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.

Donald Hunt

Hunt, Donald F.

Analytical Biochemistry

Brant Isakson

Isakson, Brant

Translating our discoveries in the microcirculation to tangible benefits in patients.

Kevin Janes

Janes, Kevin A.

Systems-biology approaches to cancer biology and virology.

David Kashatus

Kashatus, David F

The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

Peter Kasson

Kasson, Peter M.

Mechanisms of cell entry by influenza; Viral glycan recognition; drug resistance; molecular dynamics simulation; distributed computing.

Dean Kedes

Kedes, Dean H.

Human Herpes virus associated with malignancy, including Kaposi's Sarcoma

Raymond Keller

Keller, Raymond E.

Cellular and molecular mechanisms of morphogenesis

Susanna Keller

Keller, Susanna R.

Insulin signaling, insulin-regulated membrane trafficking and associated changes in cellular function and whole body physiology

Kimberly Kelly

Kelly, Kimberly

Advancement in the design of imaging agents; molecular imaging and radiological sciences.

Mark Kester

Kester, Mark

Nanotechnologies for targeted drug delivery

Jonathan Kipnis

Kipnis, Jonathan

Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration

Keith Kozminski

Kozminski, Keith G.

Regulation of Polarized Morphogenesis

Sarah Kucenas

Kucenas, Sarah C.

The role of glia in the development, maintenance and regeneration of the nervous system

Gordon Laurie

Laurie, Gordon W.

Role of Prosecretory Mitogen 'Lacritin' in Epithelial Homeostasis, Secretion and Innate Defense

Norbert Leitinger

Leitinger, Norbert

Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes

Chien Li

Li, Chien

Neuroendocrine regulation of energy balance and stress, regulation of pancreatic islet hormone secretion and glucose homeostasis

Hui Li

Li, Hui

Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development

Ulrike Lorenz

Lorenz, Ulrike M

Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways

Xiaowei Lu

Lu, Xiaowei

Developmental regulation of planar cell polarity in the mammalian nervous system

Kevin Lynch

Lynch, Kevin R.

Chemical biology of sphingosine 1-phosphate

Mani Mahadevan

Mahadevan, Mani S.

Molecular Mechanisms of Myotonic Muscular Dystrophy

Barbara Mann

Mann, Barbara J.

Pathogenicity of Francisella tularensis and vaccines

Marty Mayo

Mayo, Marty W.

Transcriptional Regulation by NFKB

Michael McConnell

McConnell, Michael J

The Cause and Consequence of Somatic Mosaicism in Neurons

Wladek Minor

Minor, Wladek

Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility

Robert Nakamoto

Nakamoto, Robert K.

Structure-Function of Active Transporters

Eyleen O'Rourke

O’Rourke, Eyleen Jorgelina

Obesity and Aging

Gary Owens

Owens, Gary K.

Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke

Jason Papin

Papin, Jason A.

Systems biology, infectious disease, cancer, toxicology, metabolic engineering

Bryce Paschal

Paschal, Bryce M.

Nuclear Transport, Signaling, and Cancer

Manoj Patel

Patel, Manoj

Modulation of sodium channel gating by beta subunits and novel sodium channel blockers; Synaptic transmission in dorsal horn neurons

Shayn Peirce-Cottler

Peirce-Cottler, Shayn M.

Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

Lucy Pemberton

Pemberton, Lucy F.

Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

Edward Perez-Reyes

Perez-Reyes, Edward

Exploring epilepsy circuits then preventing seizures using AAV-based gene therapies.

Kenneth Pfister

Pfister, K. Kevin

Regulation of Cytoplasmic Dynein for Membrane Bounded Organelle Trafficking in Axons

Owen Pornillos

Pornillos, Owen

Structure and assembly of HIV Virus/host interactions; Structural biology of the innate immune system

No Photo Available

Provencio, Ignacio

The Role of Melanopsin Retinal Ganglion Cells in the Photic Regulation of Mammalian Circadian Rhythms

Aaron Quinlan

Quinlan, Aaron R.

Bioinformatics and computational genomics; Variation in genome structure; Somatic genome evolution; Cancer genome biology

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

David Rekosh

Rekosh, David M.

Human Immunodeficiency; Virus Gene Expression

Jeffrey Saucerman

Saucerman, Jeffrey J.

Roles of complex signaling networks involved in the regulation of cardiovascular function and disease

Dorothy Schafer

Schafer, Dorothy A.

Mechanisms of actin assembly during cell migration and membrane traffic

Weibin Shi

Shi, Weibin

Cellular and genetic determinants of atherosclerosis and restenosis.

Sarah Siegrist

Siegrist, Sarah

Regulation of neural stem cell proliferation by extracellular factors, local and systemic. Intrinsic signaling programs regulating neural stem cell fate decisions: death versus survival. Functional and molecular similarities between Drosophila and mammal

Jeffrey Smith

Smith, Jeffrey S.

Transcriptional Silencing and Aging in Yeast

M. Smith

Smith, M. Mitchell

Functional Genomics of Histones, Chromatin, and Protein Acetylation Signaling in Cancer and the Cell Cycle

Avril Somlyo

Somlyo, Avril V.

Novel signal transduction pathways in smooth muscles that regulate contractility and impact diseases of the vasculature, airway and gastrointestinal tract.

P. Todd Stukenberg

Stukenberg, P. Todd

Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors

Ann Sutherland

Sutherland, Ann E.

Cell behavior and morphogenesis during early mouse development.

No Photo Available

Tamm, Lukas K.

Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions

Angela Taylor

Taylor, Angela M.

Diabetic cardiovascular disease - early diagnosis and prevention; Women's heart disease.

Bernard Thisse

Thisse, Bernard V.

Molecular control of embryonic development

Christine Thisse

Thisse, Christine I.

Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine

Michael Timko

Timko, Michael P.

Gene regulation during host-parasite interaction

No Photo Available

Tung, Kenneth S.

Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens

B. Venton

Venton, B. Jill

Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents

Michael Weber

Weber, Michael J.

Targeting Cell Signaling for Cancer Therapy.

Judith White

White, Judith M.

Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics

No Photo Available

Wiener, Michael C.

Structural biology (esp. crystallography) of integral membrane proteins; TonB-dependent active transport across the bacterial outer membrane; cancer-related membrane proteins; crystallization methods development

Bettina Winckler

Winckler, Bettina

Endosomal function and dysfunction in neurons. Wiring the nervous system in development.

Martin Wu

Wu, Martin

Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts

David Wotton

Wotton, David

Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling

Mark Yeager

Yeager, Mark

Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus

Jing Yu

Yu, Jing

Mammalian kidney development

J. Julius Zhu

Zhu, J. Julius

Neural Circuits in Healthy and Diseased Brains

Jochen Zimmer

Zimmer, Jochen

Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.

Hui Zong

Zong, Hui

Early detection, cancer prevention, and tumor microenvironment