We ensure that trainees are exposed to the breadth of biological approaches throughout their training years. To that end, there is a large network of UVA researchers from 3 schools and 10 departments to provide a comprehensive graduate training program in modern cell and molecular biological sciences. In addition there is a tremendous amount of collaboration among the CMB faculty as illustrated by the network of collaborative publications.
Basic and translational brain tumor research
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Molecular Mechanisms of Transcriptional Regulation
Regulation of low-voltage activated T-type Ca2+ channel activity by kinases and heterotrimeric G-proteins and their roles in physiological responses.
Mechanisms of neuromodulation in central neurons
Circuit mechanisms of sleep and epilepsy
Physical Modeling of Microarray Hybridization; Analysis of Genomic Tiling Array Data; Bioinformatics; Computational Biology; Regulatory Networks
Epigenetic Silencing Mechanisms-Implications in Breast Cancer and Rett Syndrome
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Signaling Pathways and Breast Cancer
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Engineering biomaterials as cellular microenvironments
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Systems Genetics Approaches to Understand Cardiometabolic Traits
Herpes Simplex Virus Infection of Neurons
Biophysical Chemistry: Membrane protein structure, function, and dynamics
Regeneration and Developmental Biology of the Hearing and Balance Organs in the Vertebrate Ear.
Cellular and molecular mechanisms of Neisserial pathogenesis
Elucidating and Understanding the Mechanisms Underlying Nervous System Development
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Cell Adhesion and Adhesion-Dependent Cell Signaling in Vertebrate Morphogenesis
Genomic Instability in Cancer Cells; Noncoding RNAs in differentiation and cancer; Bioinformatics of cancer outcome
Neural Development; Cell Division in Neural Stem Cells; Axon Outgrowth and Guidance
Structure and Function of Macromolecular Complexes Using Electron Microscopy
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity
Immune mechanisms of pathogenic antibody production in allergy and autoimmunity
Systems Genetics of Skeletal Development and Maintenance
Signal transduction in cancer cells
Transcription; Chromatin Modifications, Neurodegenerative Disease, Cancer
Mechanisms of Genetic and Metabolic Adaptation in the Malaria Parasite, Plasmodium falciparum
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Molecular genetics; development and function of neurotransmitter-synthesizing neurons in Drosophila
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Translating our discoveries in the microcirculation to tangible benefits in patients.
Systems-biology approaches to cancer biology and virology.
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Physical mechanisms of infectious disease; influenza infection; membrane fusion; antibiotic resistance; molecular dynamics simulation; machine learning.
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Advancement in the design of imaging agents; molecular imaging and radiological sciences.
Architecture and function of biological membranes
Nanotechnologies for targeted drug delivery
The role of glia in the development, maintenance and regeneration of the nervous system
Restoration of Homeostasis in Disease
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Hair cell development and innervation and mouse models for human deafness Wnt/PCP signaling and biomechanical regulation of neural tube closure
Chemical biology of sphingosine 1-phosphate
Molecular Mechanisms of Myotonic Muscular Dystrophy
Transcriptional Regulation by NFKB
Structure-Function Relationships in Macromolecules; Infectious Diseases and Drug Discovery; Bioinformatics and Big Data; Scientific Reproducibility
Cell signaling, hematopoietic stem cell biology, molecular and epigenetic mechanisms of leukemia.
Obesity and Aging
Identification of Factors and Mechanisms that Regulate the Stability of Late Stage Atherosclerotic Lesions and the Probability of Thromboembolic Events Including a Heart Attack or Stroke
Systems biology, infectious disease, cancer, toxicology, metabolic engineering
Developmental Genetics, Evolution and Regeneration
Mechanisms of organ development and homeostasis and tumor development
Nuclear Transport, Signaling, and Cancer
Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Exploring epilepsy circuits then preventing seizures using gene therapies. Developing drug-inducible genetic switches for insulin replacement gene therapies.
Structure and assembly of HIV, virus/host interactions, structural biology of the innate immune system
Novel therapeutic approaches to brain cancers and to other neurologic diseases
Apoptotic cell clearance mechanisms in health and disease
Chromosome segregation and aneuploidy in meiosis and mitosis
Human Immunodeficiency; Virus Gene Expression
Roles of complex signaling networks involved in the regulation of cardiovascular function and disease
computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning
Molecular and genetic determinants of atherosclerosis and cardiometabolic disorders.
Regulation of neural stem cell proliferation during development and adulthood
Transcriptional Silencing and Aging in Yeast
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Biomembrane Structure and Function; Cell Entry of Enveloped Viruses; Neurosecretion by Exocytosis; Structure of Bacterial Pathogen Membrane Proteins; Lipid-Protein Interactions
Molecular Mechanisms of Early Vertebrate Development and Morphogenesis. Application to Stem Cell Biology and Regenerative Medicine
Analytical Neurochemistry; Dopamine and Serotonin Neurotransmission in Drosophila; Mechanisms of rapid adenosine signaling in rodents
Genome instability in cancer and repeat expansion diseases
Structure/function of integral membrane proteins; structural biophysics; enzymology and virology of ZMPSTE24; sparse-constraint structure determination; technology development
Endosomal function and dysfunction in neurons. Development of the nervous system: cytoskeleton and membrane traffic in axon and dendrite growth.
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts
Cardiac Gap Junction Membrane Channels / Integrins Water Channels / Rotavirus / Reovirus / Retrovirus
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysic
Neural Circuits in Healthy and Diseased Brains
Transport of biopolymers across biological membranes with a particular interest in polysaccharide and protein translocation.
Early detection, cancer prevention, and tumor microenvironment