Gene Structure and Expression
Within the past decade, there has been remarkable progress in our understanding of the structure of genes, the mechanism of their expression, and the identification of factors regulating this expression in response to environmental or developmental signals. An understanding of gene regulation is vital for understanding the control of normal cell proliferation and differentiation, as well as the molecular basis of deregulated cell growth that occurs in many human diseases including cancer.
This knowledge is obtained both by direct biochemical analysis of the protein-protein and protein-DNA interactions that are essential for gene regulation and by genetic studies, which can reveal the functional relationships of those cellular factors that control the expression of a gene and thus complement the biochemical approaches. Both bacterial and eukaryotic cell systems(including yeast, plants, invertebrates and vertebrates) are providing both general and specific information about gene expression.
Faculty in this Area:
Bekiranov, Stefan
Computational Biology; Bioinformatics; Precision Medicine; Machine Learning/AI; Quantum Computing
Bushweller, John H.
Drug Development Targeting Transcription Drivers in Cancer; Structure/Function Studies of Transcription Factor Drivers in Cancer
Jiang, Hao
Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)
Li, Hui
Gene regulation in cancer, RNA processing; Epigenetic modification; Stem cell and development
Mohi, Golam
Cell signaling, stem cell biology, molecular and epigenetic mechanisms of blood and breast cancers
Rekosh, David M.
Human Immunodeficiency Virus Gene Expression; Human Endogenous Viruses; SARS-CoV-2 Protein Trafficking; Post-transcriptional Gene Regulation
Sheffield, Nathan
computational biology & bioinformatics; high performance computing; epigenomics & chromatin; pediatric cancer; computational regulatory genomics; machine learning
Stukenberg, P. Todd
Mechanisms of chromosome segregation in Mitosis and generation of Chromosomal Instability in tumors
Wotton, David
Regulation of Gene Expression, Development and Tumor Progression by TGF beta Signaling
Wu, Martin
Research: microbial evolution and ecology, microbial genomics, metagenomics, bioinformatics, phylogenomics, endosymbionts
Zang, Chongzhi
Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Advanced machine learning; Theoretical and computational biophysics