Publications

McLaughlin N, Yao X, Li Y, Saifudeen Z, and El-Dahr SS. Histone signature of metanephric mesenchyme cell lines. Epigenetics 8(9):970-8, 2013. PMCID:PMC3883774

Forbes MS, Thornhill BA, Galarreta CI, Minor JJ, Gordon KA, Chevalier RL. Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli. Am J Physiol Renal Physiol 305:F1736-F1746, 2013 PMCID 3882445

Chevalier RL, Forbes MS, Galarreta CI, Thornhill BA. Responses of proximal tubular cells to injury in congenital renal disease: Fight or flight. Pediatr Nephrol 29:537-541, 2013 PMCID:PMC3925758

Li Y, Liu J, McLaughlin N, Bachvarov, D,Saifudeen Z and El-Dahr SS. Genome-wide Analysis of the p53 Gene Regulatory Network in the Developing Mouse Kidney. Physiol Genomics. 2013 Sep 3. PMCID: PMC3798767

El-Dahr SS, Hilliard S, Aboudehen K, Saifudeen Z. The MDM2-p53 pathway: multiple roles in kidney development. Pediatr Nephrol. 2013 Sep 28. PMCID: PMC3969418

Lin, EE, Sequeira-Lopez, MLS and Gomez, RA. RBP-J in Foxd1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells. Am J Physiol-Renal 2014 Jan;306(2):F249-58 PMCID:PMC3920017

McLaughlin N, Wang F, Saifudeen Z, and El-Dahr SS. In situ histone landscape of nephrogenesis. Epigenetics 9(2):222-35, 2014. PMCID:PMC3962532

Galarreta CI, Grantham JJ, Forbes MS, Maser RL, Wallace DP, Chevalier RL. Tubular obstruction leads to progressive proximal tubular injury and atubular glomeruli in polycystic kidney disease. Am J Pathol 2014 Jul;184(7):1957-66. PMCID: PMC4076474

Li Y, Liu J, Li W, Feng Y, Li M, El-Dahr S and Saifudeen Z. p53 Enables Metabolic Fitness and Self-Renewal of Nephron Progenitor Cells. Development 2015 Apr 1:142(7):1228-41. PMCID: PMC4378244

Sequeira Lopez MLS, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. Am J Physiol Regul Integr Comp Physiol. 2015;308(2):R138-49. PMCID: PMC429786

Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS. Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15:142(6):1180-92. PMID: 257582272.

Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Loss of Jagged1 in Renin Progenitors Leads to Focal Kidney Fibrosis. Physiol Rep. 2015 Nov; 3(11). PMCID: PMC4673620

Adli M, Parlak M, Li Y, El-Dahr SS. Epigenetic States of nephron progenitors and epithelial differentiation. J Cell Biochem. 2015 Jun:116(6):893-902. PMID: 255604333.

Chevalier RL. Congenital urinary tract obstruction: The long view. Adv Chronic Kidney Dis. 2015 Jul;22(4):312-9. PMCID: PMC4475271

Sergio M, Galarreta CI, Thornhill BA, Forbes MS, Chevalier RL. The fate of nephrons in congenital obstructive nephropathy: Adult recovery is limited by nephron number despite early release of obstruction. J Urol. 2015 Nov;194(5):1463-72. PMCID: PMC4615464 [Available on 2016-11-01]

Singh R, Kuscu C, Quinlan A, Qi Y, Adli M. Cas9-chromatin binding information enables more accurate CRISPR off-target prediction. Nucleic Acids Res. 2015 Oct 15;43(18):e118. PMCID: PMC4605288

Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. 2016 May;67(5):992-9. PubMed PMID: 26928806; PubMed Central PMCID: PMC4833511.

Gomez RA, Sequeira-Lopez ML. Novel Functions of Renin Precursors in Homeostasis and Disease. Physiology (Bethesda). 2016 Jan;31(1):25-33. PubMed PMID: 26661526; PubMed Central PMCID: PMC4698453.

Hu Y, Li M, Göthert JR, Gomez RA, Sequeira-Lopez ML. Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development. J Am Soc Nephrol. 2016 Jul;27(7):1984-95. PubMed PMID: 26534925. (Epub ahead of print) [PMCID In Progress]

Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7. PubMed PMID: 26246508; PubMed Central PMCID: PMC4591368.

Lin EE, Pentz ES, Sequeira-Lopez ML, Gomez RA. Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R576-84. PubMed PMID: 26180185; PubMed Central PMCID: PMC4591380.

Sequeira-Lopez, MLS, Torban E. New insights into precursors of the renal endothelium. Kidney Int (In press) 2016. [PMCID in progress]

Liu, H, Chen S, Yao X, Li Y, Saifudeen Z, El-Dahr SS. Histone Deacetylases 1 and 2 balance nephron progenitor renewal and differentiation during kidney organogenesis. In preparation.

Abstracts and talks

Eugene E Lin, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. RBP-J controls the fate of the kidney vasculature. Poster presented at High Blood Pressure Research 2012 Scientific Sessions, September, 2012, Washington, DC, USA

Zubaida Saifudeen, Jiao Liu, Yuwen Li, Thomas Carroll and Samir S. El-Dahr. P53 Regulates Progenitor Cell Renewal in the Nephrogenic Niche of the Developing Kidney. Poster presentation, American Society of Nephrology, San Diego, Nov. 2012.

El-Dahr, S. Chromatin-based mechanisms of nephron progenitor cell renewal and fate’ presented at the International Workshop in Developmental Nephrology (IWDN-2013) in Edinburgh, Scotland, June 24-26, 2013.

Zubaida Saifudeen. p53 in Nephron Differentiation. Invited speaker, American Society of Nephrology, Atlanta, Nov. 2013.

Eugene E Lin, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Foxd1+ stromal cells, the required progenitor for renal vascular development. Oral presentation at High Blood Pressure Research 2013 Scientific Sessions, September, 2013, New Orleans, LA, USA.

Eugene E Lin, Ellen S Pentz, Minghong Li, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. The Notch signaling pathway regulates the fate of renal FOXD1+ stromal cells and their descendants. Poster presentation at High Blood Pressure Research 2014 Scientific Sessions, September, 2014, San Francisco, CA, USA

Lin EE, Sequeira-Lopez MLS, Gomez RA. The Notch signaling pathway regulates the fate of renal FOXD1+ stromal cells and their descendants. Poster presentation at High Blood Pressure Research 2014 Scientific Sessions, September, 2014, San Francisco, CA, USA.

Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Jagged1 and Morphological Integrity of the Kidney. September 2014. High Blood Pressure Research Conference. San Francisco, California. Poster presentation.

Lin EE, Pentz ES, Sequeira-Lopez MLS, Gomez RA. Foxd1+ stromal cells: the progenitors for kidney vascular development. Oral presentation at the National Kidney Foundation’s Spring Clinical Meetings, 2015.

Silvia Medrano, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Hypoxia and kidney vascular pathology. Poster presentation at the 27th Annual Children’s Hospital Research Symposium, University of Virginia, Charlottesville, VA, USA. May 28, 2015.
Lin EE, Pentz ES, Sequeira-Lopez MLS, Gomez RA. Foxd1+ stromal cells: the progenitors for kidney vascular development. Oral presentation at the Nephrology Young Investigator’s Forum, Mid-Atlantic Regional, 2015.

Belyea BC, Xu F, Sequeira-Lopez MLS, Gomez RA. Loss of Jagged1 in Renin Progenitors Leads to Focal Kidney Fibrosis. July 2015. International Workshop on Developmental Nephrology. Snowbird, Utah. Poster Presentation

Maria Florencia Martinez, Ellen Pentz, Silvia Medrano, Masafumi Oka, Mazhar Adli, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Super-Enhancers in the renin cell. Oral presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.

Evan Brown, Stephen Turner, Alex Koppel, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. Use of single cell RNA-sequencing for characterizing renin cell populations. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.

Silvia Medrano, Evan Brown, Maria Florencia Martinez, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Use of a CRISPR/Cas9 system for renin cell lineage specification. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.

Masafumi Oka, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez. Renin cells contribute to vascular pathology in renin deficient mice. Poster presentation at the 28TH Annual Research Symposium, CHRC, UVA. May 2016.

Abate, HW; Pearl, VM; Sequeira-Lopez, ML; Charlton, JR. The duration of nephrogenesis is not compromised by premature birth in mice. Poster presentation. University of Virginia’s Children’s Hospital Research Day, 2016.

Maria F Martinez, Silvia Medrano, Masafumi Oka, Ellen S Pentz, Allan W Dickerman, Mazhar Adli, Maria Luisa S. Sequeira-Lopez and R. Ariel Gomez. Enhancer Repertoires that Define Renin Cell Identity. Oral presentation. Council on Hypertension, AHA Meeting 2016.

Masafumi Oka, Silvia Medrano, Maria Luisa Sequeira-Lopez, Robert Ariel Gomez. Cells Programmed For The Renin Phenotype Contribute To Vascular Pathology In Renin Deficient Mice. Oral presentation. Council on Hypertension, AHA Meeting 2016.

Silvia Medrano, Evan Brown, Maria F Martinez, Maria Luisa S Sequeira-Lopez, R Ariel Gomez. Use of a CRISPR/Cas9 System for Specification of the Renin Cell Phenotype. Poster presentation. Council on Hypertension, AHA Meeting 2016.

Vidya K. Nagalakshmi, Minghong Li, R. Ariel Gomez, Maria Luisa S. Sequera-Lopez. Cell Fate Changes During Tubular Damage and Regeneration in the Mouse Kidney. Oral presentation. Council on Hypertension, AHA Meeting 2016.

Maria Luisa S. Sequeira Lopez, Brian C. Belyea, Rajwinderjit Kaur, Silvia Medrano and R. Ariel Gomez. CD44 and CD44+ cells are dispensable for the recruitment of renin expressing cells. Oral presentation. Council on Hypertension, AHA Meeting 2016.

Laws, J; Abate, HW; Pearl, VM; Sequeira-Lopez, ML; Charlton, JR. Early Cessation of Nephrogenesis in Mouse Model of Prematurity, Submitted to American Society of Nephrology’s annual meeting in November 2016.