The PCEN supports two biomedical research core laboratories to assist investigators in two important areas: 1) Single-cell transcriptome and genome analyses and 2) Genome Mapping, Manipulation, Analysis, and Bioinformatics Core.. The core laboratories are directed by experienced researchers and staffed with highly trained personnel.
The services provided by these cores enable PCEN investigators to carry out their research in a cost-effective and efficient way. Each core unit serves as a resource for all PCEN two main research projects and pilot projects at all times. In addition, these laboratories serve other investigators within the School of Medicine and the Department of Biology at UVA, as well as researchers from other institutions. Each core offers a variety of specialized and innovative research services, and provide hands-on training to scientists as well as consultation services and access to state-of-the-art research equipment for experienced users.
The scope of these cores is in line with the overall theme of this PCEN: “Kidney Development and Disease: Cell Fate and Precursors of Disease in the Young and Adult.” The experimental approaches of the PCEN involve examination of the mechanisms that control cell fate, plasticity, and identity and the cellular signals underlying the phenotypic transformation that occurs during kidney development, injury and repair. The cores provide specialized technologies and expertise needed to accomplish the goats of the PCEN.