Nov 15 2018 Joseph Larner Memorial Lecture in Pharmacology-“Female Bones and Behaviors Controlled by Sex-Dependent Hypothalamic Nodes” by Holly A. Ingraham

November 15, 2018 by Health System Enterprise Calendar

[PHCC Auditorium 1st Floor Pinn Hall] A lectureship was established to honor the memory of Joseph Larner, who served as Professor and Chair of the Pharmacology Department for many years. During his time as Chair he recruited and mentored numerous successful faculty, including Al Gilman. He continued to be an inspiration to everyone who knew him, especially our graduate students, who were in awe of his energy and enthusiasm as he kept up his science and maintained an active departmental presence well into his 90s. In addition to honoring Dr. Larner’s memory, the goal of this lectureship is to highlight exciting new advances in an area that held great interest for him: the pervasive role of metabolism/cell signaling in human disease.

About this Year’s Speaker:

Hosted by Michelle Bland and Thurl Harris, Holly A. Ingraham, PhD, is a Professor and Associate Vice Chair of Cellular and Molecular Pharmacology, Herzstein Distinguished Investigator, UCSF, San Francisco, CA

Ingraham’s lab has focused on defining the molecular mechanisms and transcriptional pathways that contribute to endocrine tissue development and function. Our approaches are broad, spanning structural biology, biochemistry and genetic mouse models. In the last several years we have worked to understand how the class of NR5A orphan nuclear receptors are regulated by both ligands and post-translational modifications, with a new focus on LRH-1 (NR5A2) because of its impact on human health. The lab recently showed that phosphoinositides are the highest affinity ligands for both SF-1 and LRH-1.