Mentors of the Immunology Training Program
The biomedical research environment at the UVA School of Medicine has a long been recognized for its scientific excellence and collegial interactions. Combined with cutting edge technological facilities, it is an ideal environment in which to train the next generation of immunologists. The ITP is grounded in an outstanding group of faculty mentors, whose research programs are based in immunology, but with an orientation towards infectious disease, cancer, development, vascular biology, or neuroscience. In keeping with this, the mentors are drawn from 8 University Departments and 7 Divisions of the Department of Internal Medicine. This diversity also brings together basic and clinically oriented scientists. Most mentor laboratories are within a 5 minute walk of one another, enhancing their participation in collaborative research and training activities. Members of this group contribute to and benefit from a rich intellectual research environment where trainees are exposed to the ideas and techniques of range of scientific disciplines necessary for productive research careers in the Immunology of the future.
Regulation of gene expression during lymphocyte development
Innate immune mechanisms of rhinovirus (RV)-induced asthma exacerbations. Immune and cellular mechanisms of asthma. Immune mechanisms in chronic hyperplastic eosinophilic sinusitis (CHES).
Signaling Pathways and Breast Cancer
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Cellular and molecular mechanisms of Neisserial pathogenesis
Ion channels and Ca2+-signaling in inflammation, immunity and tissue homeostasis
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
Innate immunity, chronic disease, host-parasite interactions
Human lymphocyte biology and autoimmunity
Exploring new therapeutics avenues to treat Multiple Sclerosis.
Recognition, diagnosis, pathogenesis, impact, treatment and prevention of enteric infections; global health and tropical infectious diseases
Immune regulation for HCV infection and chronic liver inflammation
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Immune response to infectious disease in the CNS
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Neuroimmunology and glia biology in cognition, neurodevelopment and neurodegeneration
Role of lipid oxidation products in inflammation and vascular immunology in atherosclerosis and diabetes
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Understanding How Immunological Pathways Contribute to Neurodegenerative, Neurodevelopmental, Mental and Behavior Disorders
Atherosclerosis, Obesity, Diabetes
Immune mechanisms of acute kidney injury and fibrosis. Pulsed ultrasound in acute kidney injury
Immune mechanisms of defense against enteric (diarrheal) infections
Common Allergic Diseases
Bioanalytical tools for inflammatory disease
Apoptotic cell clearance mechanisms in health and disease
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Human Tumor Cell Antigens
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Cellular and molecular mechanisms of allergic disease in humans.
Stem Cell Behavior