Potter, Aimee (Criss)
Gonorrhea is a mucosal infection caused by the pathogen Neisseria gonorrhoeae that impacts nearly 60 million people around the globe annually and is characterized by a robust inflammatory response and massive recruitment of neutrophils to the site of infection. Migration of neutrophils across epithelial barriers is thought to “prime” the anti-bacterial response. We are therefore investigating the activation state of transmigrated human neutrophils and examining how the phagocytic and degradative capacity of neutrophils is altered following transmigration towardsNeisseria gonorrhoeae. These studies will reveal how inflammation initiated by a mucosal pathogen, N. gonorrhoeae, affects human neutrophil functionality.