Phelps, Cody (Brown)
Intratumoral lymphocytes have been shown to become dysfunctional after entry into the tumor. The mechanism behind how this occurs has not been fully elucidated. In this regard, we wish to explore how the inactivation of the cGAS/STING pathway in the tumor and the resultant loss of type 1 interferon signaling could be influencing the hypofunctional phenotype of the immune cells. We will extend our studies into determining how this will in turn impact immunoediting of tumor MHC-I expression.