Lindsay, Robin (Engelhard)
Increased T cell numbers within the tumor microenvironment is correlated with longer patient survival and increased response to checkpoint blockade therapy. What factors control T cell entry and survival within the tumor microenvironment is not well understood. My work focuses on the affect innate immune cells, primarily NK cells, have on T cell presence within the tumor. Innate immune cells may affect T cell entry, survival, or proliferation within the tumor all of which may dictate how destructive the adaptive immune response is to the tumor.