Dziewulska, Karolina (Loughran)
Large Granular Lymphocyte Leukemia (LGLL) is a rare clonal malignancy of natural killer or T-cells. It is also characterized by chronic inflammation as well as autoimmunity, and as such is an interesting example of multifactorial disruption of immune homeostasis. The abnormal function and amplification of cytotoxic leukemic cells play a role in both the development and progression of complex immune dysfunction, impacting the frequencies and functionality of various blood cell subsets. Although several molecular mechanisms that sustain LGL expansion and survival have been uncovered, the currently available treatment has limited efficacy and predominantly focuses on the management of clinical manifestations. My research is dedicated to a better understanding of the etiology of immune dysregulation, and of the potential contribution of retroviral elements to LGLL progression. Resulting findings will hopefully further our comprehension of the disease biology and advance the development of new therapeutic approaches.