Bolte, Ashley (Lukens)
Traumatic brain injury (TBI) is a devastating event that results in a heightened risk for long-term sequelae including anxiety, depression, dementia, and chronic traumatic encephalopathy. Our current mechanistic understanding of the biological factors that render the TBI brain more susceptible to neurological disease later in life remains poorly understood. The recent discovery of the importance of meningeal lymphatic drainage in clearing debris from the brain has led to exciting advances in understanding diseases that affect the brain, yet very little is known about the role of the meningeal lymphatics in mediating inflammation after brain trauma. I am interested in addressing how the meningeal lymphatics regulate immune responses following TBI and how dysregulation of this draining system contributes to neurological disease.