Arneja, Abhinav (Luckey)
My research interests focus on characterizing the molecular and cellular mechanisms regulating Red blood cell (RBC) alloimmunization responses. I am particularly interested in the phenomenon of RBC alloantibody evanescence, which remains a significant clinical problem in transfusion medicine. Many RBC alloantibodies in patients are evanescent, i.e. they decrease in titers to levels below detection over time, leading to severe delayed hemolytic transfusion reaction upon subsequent transfusion with antigen positive RBCs. Despite the significant clinical consequences of RBC alloantibody evanescence, the molecular and cellular mechanisms regulating alloantibody persistence remain uncharacterized. Building on previous results in our laboratory demonstrating an important role for interleukin-6 receptor (IL-6R) signaling in regulating primary RBC alloimmunization responses, I am investigating the role of either global or cell specific IL-6R signaling in regulating RBC alloantibody persistence/evanescence using mouse models previously developed in our laboratory.