A group of genes that has been largely ignored by scientists could play critical roles in atherosclerosis (hardening of the arteries), inflammation and likely obesity and other metabolic diseases, new research suggests.
The new discovery was made in the lab of CIC member, Kodi Ravichandran, reveals the context of how our bodies recognize and remove dying cells.
“We came across the genes, called SLCs, kind of by accident,” said researcher Kodi Ravichandran, PhD, chairman of the Department of Microbiology, Immunology and Cancer Biology. “Initially, just like everybody else, we were not paying much attention to the SLCs. But they kept coming up repeatedly in our gene expression analyses, and we realized this must be relevant. Then we took a serious dive into their biology, and we had a lot of fun surprises.”