Mazhar Adli, PhD
The Adli lab is focused on understanding whole-genome level chromatin regulation in normal development (Cell, 2013) as well as disease development with a specific focus on cancer (Cancer Cell, 2012; Nature, 2012, Nature 2011). We are integrating genomic and epigenomic tools including chromatin immunoprecipiation and high throughput sequencing (ChIP-Seq) technologies to extract and study whole genome level epigenetic information to gain insight into epigenetic mechanism of chromatin structure and function in different cellular contexts. In addition to utilizing conventional functional genomics and epigenomics tools, we are also developing and applying novel technologies (Nature Methods, 2010) to study chromatin structure in limitedly available biological samples such as clinical biopsies and primary stem cells.
The lab has recently started to utilize CRIPSR/Cas9 system based gene editing technologies (Nature Biotechnology, 2014) to manipulate locus specific genetic and epigenetic information as well as high throughput knock-out screenings in human cells to identify novel regulators of cellular state transitions in normal and malignant development.
University of Virginia, School of Medicine
Department of Biochemistry and Molecular Genetics.