Ureteric bud branching morphogenesis. The ureteric bud epithelium is labeled in red. At E10.5, the ureteric bud evaginate from the Wolffian duct, indicating the onset of kidney development. At E11.5, branching morphogenesis at the tip of the ureteric bud generates a T-bud. Successive rounds of branching morphogenesis generate an extensive arborization of the ureteric bud epithelium.