Wotton Recent Publications

David Wotton, Ph.D.
Associate Professor of Biochemistry
and Molecular Genetics

Representative publications

Tgifs and development

Taniguchi, K., Anderson, A.E., Sutherland, A.E. and Wotton, D. (2012). Loss of Tgif function causes holoprosencephaly by disrupting the Shh signaling pathway. PLoS Genetics. In Press.

Powers, S.E., Taniguchi, K., Yen, W., Melhuish, T.A., Shen, J., Walsh, C.A., Sutherland, A.E. and Wotton, D. (2010). Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 137, 249-259.
Abstract

Bartholin, L., Melhuish, T.A., Powers, S.E., Goddard-Leon, S., Treilleux, I., Sutherland, A.E. and Wotton, D. (2008). Maternal Tgif is required for vascularization of the embryonic placenta. Dev. Biol. 319, 285-297.
Abstract

El-Jaick, K., Powers, S.E., Bartholin, L., Myers, K.R., Hahn, J., Lacbawan, F., Roessler, E., Wotton, D. and Muenke, M. (2007). Functional analysis of mutations in TGIF associated with holoprosencephaly. Mol. Genet. Metab. 90, 97-111.
Abstract

Tgifs and transcriptional regulation

Bjerke, G.A., Hyman-Walsh, C. and Wotton, D. (2011). Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol. Cell Biol. 31(18), 3723-33.
Abstract

Melhuish T.A., Chung, D.D., Bjerke, G.A. and Wotton, D. (2010). Tgif1 represses apolipoprotein gene expression in liver. J Cell Biochem. 111(2), 380-90.
Abstract

Hyman-Walsh, C., Bjerke, G.A., and Wotton, D. (2010). An autoinhibitory effect of the homothorax domain of Meis2. FEBS J. 277(12), 2584-97.
Abstract

Melhuish, T.A. and Wotton, D. (2006). The Tgif2 gene contains a retained intron within the coding sequence. BMC. Mol. Biol. 7, 2.
Abstract

Bartholin, L., Powers, S.E., Melhuish, T.A., Lasse, S.H., Weinstein, M. and Wotton, D. (2006). Tgif inhibits retinoid signaling. Mol. Cell. Biol. 16, 990-1001.
Abstract

Hyman, C.A., Bartholin, L., Newfeld, S.J., and Wotton, D. (2003). Drosophila TGIF proteins are transcriptional activators.  Mol. Cell. Biol. 23, 9262-9274.
Abstract

Melhuish, T.A., Gallo, C.M. and Wotton, D. (2001). TGIF2 interacts with histone deacetylase and represses transcription. J. Biol. Chem. 276, 32109-32114.
Abstract

Melhuish, T.A. and Wotton, D. (2000). The interaction of the Carboxyl terminus binding Protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275, 39762-39766.
Abstract

SUMOylation

Merrill, J.C., Kagey, M.H., Melhuish, T.A., Powers, S.E., Zerlanko, B.J. and Wotton, D. (2010). Inhibition of CtBP1 activity by Akt-mediated phosphorylation. J. Mol. Biol. 398(5), 657-71.
Abstract

Merrill, J.C., Melhuish, T.A., Kagey, M.H., Yang, S.H., Sharrocks, A.D. and Wotton, D. (2010). A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity. PLoS ONE. 5, e8794.
Abstract

Kagey, M.H., Melhuish, T.A., Powers, S.E. and Wotton, D. (2005). Multiple activities contribute to Pc2 E3 function. EMBO J. 24, 108-119.
Abstract

Kagey, M.H., Melhuish, T.A. and Wotton, D. (2003). The Polycomb protein Pc2 is a SUMO E3. Cell. 113, 127-137.
Abstract