Paschal Research Publication

Bryce M. Paschal, Ph.D.
Professor of Biochemistry and Molecular Genetics
Selected Publications:

Gioeli, D., and Paschal, B.M., (2011) Post-translational modification of the androgen receptor. Mol. Cell Endocrinol [Epub ahead of print].

Kelly, J.B., Datta, S., Snow, C.J., Chatterjee, M., Ni, L., Spencer, A., Yang, C.S., Cubenas-Potts, C., Matunis, M.J., and Paschal, B.M., (2011) The defective nuclear lamina in Hitchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Mol. Cell Biol. 31(16): 3378-95. PMCID: PMC3147792.

Kelley, J.D., Talley, A.M., Spencer, A., Gioeli, D., and Paschal, B.M. (2010) Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol. 11: 63. PMCID: PMC2929220.

Braddock, S.R., Ardinger, H.H., Yang, C.S., Paschal, B.M.and Hall, B.D. (2010) Petty syndrome and Fontaine-Farriaux syndrome: Delineation of a single syndrome. Am. J. Med. Genet A. 152A(7): 1718-23. PMID: 20583180.

Ni, L., Yang, C.S., Gioeli, D., Frierson, H., Toft, D.O., and Paschal, B.M. (2010) FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol. Cell Biol. 30(5): 1243-53. PMCID: PMC2820886.

Galgano, M.T., Conaway, M., Spencer, A.M., Paschal, B.M., and Frierson, H.F. Jr. (2009) PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. Hum Pathol. 40(10): 1434-40. PMCID: PMC2744839.

Chen, S., Kesler, C.T., Paschal, B.M., and Balk, S.P (2009) Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. J. Biol Chem. 284(38): 25576-84. PMCID: PMC2757959.

Kaikkonen, S., Jääskeläinen, T., Karvonen, U., Rytinki, M.M., Makkonen, H., Gioeli, D., Paschal, B.M., and Palvimo JJ. (2009) SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells. Mol Endocrin. PMID: 191162244.

Shank, L.C., Kelley, J.B., Gioeli, D., Yang, C.Y., Spencer, A., Allison, L.A, and Paschal, B.M. (2008) Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro. J. Biol. Chem. 283: 10568-10580. PMID: 18270197

Kelley, J.B. and Paschal, B.M. (2007) Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP. Mol Biol. Cell. 18: 4365-4376. PMID: 17761537.

Kesler, C. T., Gioeli, D., Conaway, MR, Weber, M., Paschal, B.M. (2007) Subcellular Localization Modulates AF-1 Domain Phosphorylation in the Androgen Receptor. Mol Endocrin. 21: 2071-2084. PMID: 17579212.

Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal B.M., Sladek FM. (2007) Phosphorylation of a conserved serine in the DNA binding domain of nuclear receptors alters intracellular localization. Mol Endocrinol. 21: 1297-1311. PMID: 17389749.

Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal B.M. (2007) Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Mol Cell Biol. 27(9):3390-404. PMID: 17325038.

Gioeli, D., Black,  B.E., Gordon, V., Spencer,  A., Kesler,  C.T., Eblen,  S.T., Paschal, B.M., Weber, M.J. (2006) Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization. Mol. Endocrinol. 20: 503-515.

Kehlenbach, R.H. and Paschal, B.M. (2006) Analysis of nuclear protein import and export in digitonin-permeabilized cells. In: Cell Biology: A Laboratory Handbook. J. Celis, ed. Academic Press, San Diego, pp. 267-275.

Lévesque, L., Matzat, M.H., Bor, Y., Jin, L., Berberoglu, S., Rekosh, D., Hammarskjöld, M.L., Paschal, B.M. (2006). Mutations in Tap Uncouple RNA Export Activity from Translocation through the Nuclear Pore Complex. Mol. Biol. Cell 17: 931-943.