Selected CCC Publications

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Selected Publications (Ravichandran and Elliott Labs)

Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance.   Pinney JJ, Rivera-Escalera F, Chu CC, Whitehead HE, VanDerMeid K, Nelson AM, Barbeau MC, Zent CS, Elliott MR.  Blood. 2020 Jun 1  7:blood.2020005571. doi: 10.1182/blood.2020005571. Online ahead of print.  PMID: 32556153

Metabolites released from apoptotic cells act as tissue messengers.   Medina CB, Mehrotra P, Arandjelovic S, Perry JSA, Guo Y, Morioka S, Barron B, Walk SF, Ghesquière B, Krupnick AS, Lorenz U, Ravichandran KS.  Nature. 2020 Apr;580(7801):130-135. doi: 10.1038/s41586-020-2121-3. Epub 2020 Mar 18.  PMID: 32238926

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway.  Perry JSA, Morioka S, Medina CB, Iker Etchegaray J, Barron B, Raymond MH, Lucas CD, Onengut-Gumuscu S, Delpire E, Ravichandran KS.  Nat Cell Biol. 2019 Dec;21(12):1532-1543. doi: 10.1038/s41556-019-0431-1. Epub 2019 Dec 2.  PMID: 31792382 Free PMC article.

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.   Morioka S, Maueröder C, Ravichandran KS.  Immunity. 2019 May 21;50(5):1149-1162. doi: 10.1016/j.immuni.2019.04.018.  PMID: 31117011 Free PMC article. Review.

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.  Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, Cohen AH, Gaultier A, Conrads TP, Kim M, Elliott MR, Ravichandran KS.  Nat Immunol. 2019 Feb;20(2):141-151. doi: 10.1038/s41590-018-0293-x. Epub 2019 Jan 14.  PMID: 30643265 Free PMC article.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.  Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS.  Nature. 2018 Nov;563(7733):714-718. doi: 10.1038/s41586-018-0735-5. Epub 2018 Nov 21.  PMID: 30464343 Free PMC article.

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.   Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR.  Cell Death Differ. 2017 Mar;24(3):559-570. doi: 10.1038/cdd.2016.159. Epub 2017 Jan 6.  PMID: 28060378 Free PMC article.

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation.  Han CZ, Juncadella IJ, Kinchen JM, Buckley MW, Klibanov AL, Dryden K, Onengut-Gumuscu S, Erdbrügger U, Turner SD, Shim YM, Tung KS, Ravichandran KS.  Nature. 2016 Nov 24;539(7630):570-574. doi: 10.1038/nature20141. Epub 2016 Nov 7.  PMID: 27820945 Free PMC article.

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo.  Lee CS, Penberthy KK, Wheeler KM, Juncadella IJ, Vandenabeele P, Lysiak JJ, Ravichandran KS.  Immunity. 2016 Apr 19;44(4):807-20. doi: 10.1016/j.immuni.2016.02.005. Epub 2016 Mar 29.  PMID: 27037190 Free PMC article.

The Dynamics of Apoptotic Cell Clearance.   Elliott MR, Ravichandran KS.  Dev Cell. 2016 Jul 25;38(2):147-60. doi: 10.1016/j.devcel.2016.06.029.  PMID: 27459067 Free PMC article. Review.

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.  Fond AM, Lee CS, Schulman IG, Kiss RS, Ravichandran KS.  J Clin Invest. 2015 Jul 1;125(7):2748-58. doi: 10.1172/JCI80300. Epub 2015 Jun 15.  PMID: 26075824 Free PMC article.

Phagocytosis of apoptotic cells in homeostasis.   Arandjelovic S, Ravichandran KS.  Nat Immunol. 2015 Sep;16(9):907-17. doi: 10.1038/ni.3253.  PMID: 26287597 Free PMC article. Review.

Unexpected link between an antibiotic, pannexin channels and apoptosis.  Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS.  Nature. 2014 Mar 20;507(7492):329-34. doi: 10.1038/nature13147. Epub 2014 Mar 12.  PMID: 24646995 Free PMC article.

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.  Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS.  Nature. 2013 May 9;497(7448):263-7. doi: 10.1038/nature12135. Epub 2013 Apr 24.  PMID: 23615608 Free PMC article.

Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation.  Juncadella IJ, Kadl A, Sharma AK, Shim YM, Hochreiter-Hufford A, Borish L, Ravichandran KS.  Nature. 2013 Jan 24;493(7433):547-51. doi: 10.1038/nature11714. Epub 2012 Dec 12.  PMID: 23235830 Free PMC article.

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein.  Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS.  Nature. 2011 Aug 21;477(7363):220-4. doi: 10.1038/nature10340.  PMID: 21857682 Free PMC article.

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis.  Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS.  Nature. 2010 Oct 14;467(7317):863-7. doi: 10.1038/nature09413.  PMID: 20944749 Free PMC article.

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo.  Elliott MR, Zheng S, Park D, Woodson RI, Reardon MA, Juncadella IJ, Kinchen JM, Zhang J, Lysiak JJ, Ravichandran KS.  Nature. 2010 Sep 16;467(7313):333-7. doi: 10.1038/nature09356.  PMID: 20844538 Free PMC article.

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.  Kinchen JM, Ravichandran KS.  Nature. 2010 Apr 1;464(7289):778-82. doi: 10.1038/nature08853. Epub 2010 Mar 21.  PMID: 20305638 Free PMC article.

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.  Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS.  Nature. 2009 Sep 10;461(7261):282-6. doi: 10.1038/nature08296.  PMID: 19741708 Free PMC article.

A pathway for phagosome maturation during engulfment of apoptotic cells.  Kinchen JM, Doukoumetzidis K, Almendinger J, Stergiou L, Tosello-Trampont A, Sifri CD, Hengartner MO, Ravichandran KS.  Nat Cell Biol. 2008 May;10(5):556-66. doi: 10.1038/ncb1718. Epub 2008 Apr 20.  PMID: 18425118 Free PMC article.

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.  Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS.  Nature. 2007 Nov 15;450(7168):430-4. doi: 10.1038/nature06329.  PMID: 17960134

Network analysis of oncogenic Ras activation in cancer.  Stites EC, Trampont PC, Ma Z, Ravichandran KS.  Science. 2007 Oct 19;318(5849):463-7. doi: 10.1126/science.1144642.  PMID: 17947584