Elliott Laboratory

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About

The focus of our research is to understand, at a mechanistic level, the function of tissue-resident macrophages as effectors of innate immunity in acute and chronic inflammation, infection, and cancer. Macrophages are a phenotypically diverse, multifunctional population of immune cells found in every tissue in the body that play key roles in maintaining normal tissue function and immune defense against pathogens. Our work focuses on defining the molecular pathways that regulate macrophage motility, phagocytosis and inflammatory responses related to their roles in the clearance of dying cells and cancer cells. We use a wide range of basic and advanced genetic, biochemical, and imaging techniques to address these questions. Through ongoing collaborations with multiple basic and clinical labs, we ultimately seek to translate our research efforts into new disease therapies that harness the powerful immune-regulating properties of macrophages.

Contact

Michael Rusty Elliott
Associate Professor, Microbiology, Immunology, and Cancer Biology

Office: 434-982-3227
Lab: 434-982-6192
Fax: 434-982-1071

Address:
Pinn Hall, Room 4080
University of Virginia
PO Box 800734
Charlottesville, VA 22908

Laboratory Technician

Laurey Comeau

Laurey Comeau
Technician
email: lc6v@virginia.edu
phone: 434-982-6192

Post-Doctoral Fellows

 

Fátima Rivera-Escalera

Fátima Rivera-escalera, Ph.D.
Postdoctoral Fellow
email: fr7m@virginia.edu
phone: 434-982-6192
My research focuses on investigating how age-associated changes in tissue resident macrophage function contribute to inflammatory disease and cancer immunotherapy resistance.


Gamze Cömertpay

Gamze Cömertpay, Ph.D.
Postdoctoral Fellow
email: gc2ej@virginia.edu
phone: 434-982-6192
My research focuses on understanding the role of macrophages in red blood cells production and clearance.  I am also interested in elucidating mechanisms of effercytosis by tissue resident macrophages.


Graduate Students

Casey Bauchle

Casey Bauchle
Graduate Student
email: cjb2cf@virginia.edu
phone: 434-982-6192
My research focuses on examining the role of receptor tyrosine kinases in microglia-mediated clearance of amyloid beta plaques in the context of Alzheimer’s disease.


Rossymar Rivera

Rossymar Rivera
Graduate Student
email: rr5fr@virginia.edu
phone: 434-982-6192
My research is focused on understanding how complement-mediated Antibody-Dependent Cellular Phagocytosis (ADCP) induce hypophagia in macrophages.